Apr 01, 2003 · Breast cancer is the most common malignancy in United States women, accounting for >40,000 deaths each year. These breast tumors are comprised of phenotypically diverse populations of breast cancer cells. Using a model in which human breast cancer cells were grown in immunocompromised mice, we found that only a minority of breast cancer cells had the ability to form Cited by: 10596. Apr 01, 2003 · It is known that breast cancer cells are genetically unstable, and thus individual breast cancer cells from the tumorigenic population may sometimes be unable to proliferate as a consequence of chromosomal aberrations acquired during mitosis (21–23). Nevertheless, the observation that in eight of nine tumor specimens the tumorigenic Cited by: 10596.
Apr 10, 2019 · Reprogramming the Pro-Tumorigenic Immune Microenvironment to Anti-Tumorigenic in Breast Cancer. Posted April 10, 2019 Lalita A. Shevde, Ph.D., University of Alabama at Birmingham Dr. Lalita Shevde, University of Alabama at Birmingham. The immune system, normally responsible for finding and destroying cancer cells throughout the body, is often. Apr 01, 2003 · Using a model in which human breast cancer cells were grown in immunocompromised mice, we found that only a minority of breast cancer cells had the ability to form new tumors. We were able to distinguish the tumorigenic (tumor initiating) from the nontumorigenic cancer cells based on cell surface marker expression.Cited by: 10596.
Jan 18, 2007 · The methods used to isolate tumorigenic breast-cancer cells and normal breast epithelium are described in detail in the Supplementary Appendix, available with the full text of this article at www Cited by: 1066. Jun 09, 2008 · The identification of potential breast cancer stem cells is of importance as the characteristics of stem cells suggest that they are resistant to conventional forms of therapy. Several techniques have been proposed to isolate or enrich for tumorigenic breast cancer stem cells, including (a) culture of cells in non-adherent non-differentiating conditions to form mammospheres and (b) sorting Cited by: 318.